all free for you

2009-07-19T22:43:00.000-07:00

2009-06-18T20:44:00.000-07:00

if you are living with cancer we are here for you.

MANAGING YOUR MEDICAL EXPENSES

2009-06-16T08:23:00.000-07:00

The volume of paperwork involved in managing insurance claim forms, co-pays, benefits statements, etc., can be overwhelming for a mesothelioma patient who is trying to concentrate on their health care, but by keeping organized, accurate records, you can eliminate unnecessary stress.

Perhaps the simplest way of keeping information to be referred to when filing an insurance claim, is to use a paper calendar to make note of all doctor's appointments, lab tests, procedures and treatments, as well as prescription drugs purchased. If this information is recorded on the day it occurs, you will have a complete chronological record when you need it. Other records you should organize in an expandable folder or binder include:

Bills from all health care providers.
Bills or receipts for prescription drugs.
Receipts from co-pays or other health care related costs.
Insurance claims filed.
Reimbursements received.

Keeping medical expenses entered on a basic computer spreadsheet is another option, or, there is specialized software available for those who prefer a better display of information and the ability to search for and sort information. One of these programs is the "Medical Expense Manager" offered by Quicken. This program will allow you to track and organize medical expenses, tax deductions, medical and prescription history for multiple individuals, insurance payments and deductibles and billing or claims disputes.

Another alternative is to hire someone to manage your claims for you, and if you feel you need professional help, there are health insurance claims assistance services available in many areas. These professionals can file and track claims, contact health care providers and insurance companies to resolve claim issues, review medical bills for accuracy and appeal rejected claims. Fees for services rendered can vary significantly according to provider.

For those with Medicare coverage, a health insurance assistance program is available in every state. Counselors can help Medicare recipients understand their benefits, and can make suggestions on establishing a record keeping system.

all the above information is obtained from the following link.

http://www.mesotheliomaweb.org/managingexpenses.htm

MANAGING YOUR MEDICATIONS

2009-06-16T08:12:00.000-07:00

Before you were diagnosed with mesothelioma, you may have been taking a small number of medications, or perhaps, none at all. Now, it is possible you have been prescribed several different drugs, and you may be taking over-the-counter medications as well. With the added stress of disease or treatment-related symptoms, it can be easy to confuse medications or simply to inadvertently miss taking a dose. Following are some easy ways to help organize and manage your medications:

Compile a complete list of all drugs you are taking, including both their brand and generic names (i.e., Tylenol = acetaminophen), the dosage amount, times they are to be taken and any additional instructions (i.e., take with food, take before bedtime, etc.). This list should include both prescription and over-the-counter drugs, as well as any herbal supplements or vitamins you may be taking.
When a new medication is prescribed, find out the name of the drug, how and when it should be taken, whether there can be any interactions with other medications, foods or beverages, what side effects are possible and what to do if you miss a dose. Write down this information and include it on your list.
If possible, purchase all medications from the same pharmacy so that the records of what you purchased will be all in one place. Keep the patient information that is attached to prescriptions in case you need to refer to it later.
If you need help organizing dosage schedules or have questions about medications you are taking, talk to your doctor, physician's assistant, nurse or pharmacist.
Read and keep package inserts that come with your prescription medicine. This is not highly technical material or useless boilerplate wording. It is directly relevant to your experience with the medicine. More on package inserts.
Read the label on the drug container before you taking any medication. If you are confused or can't read the label, have someone else read it to be sure you are taking the right medication.
Do not skip scheduled doses. If you are taking medications for pain, they need to be taken as directed to be effective. If you have breakthrough pain between doses, follow your doctor's recommendations.
If you don't feel confident that you will remember to take your medication on schedule, set an alarm on your clock, watch, cell phone or computer.
Store medications in a safe place away from heat, light and humidity.

There are pill cases with compartments, organized by time of day, that may be helpful, and dose tracker devices such as 'Dose Dial' that will attach to any container, and can monitor the number of doses and/or the interval of doses.

Medications can play a significant role in how well you feel and can enhance, or in some cases, lessen your quality of life. Always follow directions when taking any medication, and if you have questions, concerns or are experiencing undesirable side effects you feel may be related to the drugs, speak frankly with a member of your health care team.

all the above information is obtained from the following link.

http://www.mesotheliomaweb.org/managemedications.htm

KEEPING A PERSONAL MEDICAL RECORDS FILE

2009-06-15T06:42:00.000-07:00

When you or a family member is going through the diagnostic process, or are being treated for mesothelioma, it is an undeniable fact that there will be a multitude of paperwork and reports involved. Although each individual medical professional or facility will keep its own record of your care, it is also important that you maintain an accurate, up to date medical history of your own.

It is likely that several different doctors, possibly at various locations, will be involved in your care, and each will generate a series of test results, treatment reports, scripts for medications, etc. By consolidating and organizing this information in one file, you will always have access to what you need if questions arise, or if a report is lost or inadvertently destroyed. It will also give you an opportunity to go over your records in your own time, and make note of any questions or concerns you might have. In this way, you will become a more active participant in your health care, and will feel more knowledgeable and in control of your situation. Keeping a personal medical file is also helpful in managing your health insurance claims, taxes and other legal matters.

Your personal medical record file should include the following:

Information on past medical history, including the dates and details of any previously diagnosed illnesses such as diabetes or heart disease.
Information on past physical examinations and screening tests.
Immunization records.
Contact information for all doctors, clinics and/or hospitals involved in your diagnosis, treatment or other care.
Dates of initial diagnosis and a schedule for subsequent treatments.
Copies of reports and diagnostic tests, including laboratory results, pathology reports and imaging tests (x-ray, CT, MRI, PET).
Treatment information including surgical reports, names and dosages of drugs used for chemotherapy and sites and dosages for radiation therapy.
Notes on treatment results including any complications or side effects experienced.
Information on supportive care such as pain management or nutritional support. All medications you are taking, including prescription and over the counter drugs, should be listed by name, dosage and how often they are taken.

If you have been diagnosed with mesothelioma, it is best to collect information for your file each time you have an appointment, test or procedure. At each doctor appointment, ask for any records being added to your file, and if you have a laboratory test or a procedure of any kind, request a copy of the test results or the procedure report. If you are hospitalized for any reason, request a complete copy of your hospitalization records when you are released. Keep copies of medical bills and insurance claims.

How you organize your file is a matter of personal preference. Some people prefer a filing cabinet, while others prefer a folder, binder or box; some prefer to scan documents into a computer file. Records can be divided according to date or by category such as appointments, tests or treatments. However you choose to compile your file, be sure it is stored in a safe place. You may wish to leave an additional copy with a relative or friend in case of emergency.

The Health Insurance Portability and Accountability Act of 2003 assures that all patients have access to their medical records, so if you did not start a medical file when you were first diagnosed or treated, you can still obtain the information you need. In this case, it may be necessary to request your records in writing, and you may need to complete an "Authorization to Release Medical Information". Unfortunately, requesting records after the fact can take time, and you may be charged copying fees.

Related: Managing your medications.

all the above information is obtained from the following link.

http://www.mesotheliomaweb.org/personalrecords.htm

ASBESTOS CANCER STRIKES VETERANS

2009-06-15T06:28:00.000-07:00

Many Navy retirees are now being diagnosed with asbestos-related diseases caused by exposure which occurred while serving aboard ships in the 1940s, 50s and 60s. Because of the long latency period involved in all asbestos diseases, both cancerous and non-cancerous, it may take from 20-50 years or more from initial exposure to the time symptoms begin to appear. Anyone who served aboard ship or worked in the shipyards is at risk.

During and after World War II, the use of asbestos on U. S. Navy ships was greatly expanded as asbestos manufacturers helped in writing ship product specifications. This caused thousands of shipyard workers who helped lay down new ships, and sailors who served aboard them or helped with overhaul in dry dock, to be unknowingly exposed to dangerous asbestos dust when they cut, sawed, mixed or tore out products. Typical products included insulation used on boilers or other high temperature vessels, pipe covering, firebrick, asbestos cement, fireproofing sprays, asbestos gaskets and packing and asbestos cloth and gloves. Those who worked aboard ship as machinist mates, boiler tenders and firemen, as well as those working on aircraft, or in communications or construction, were exposed daily in the course of doing their jobs. Shipyard workers such as insulators, shipfitters, pipe fitters, welders, electricians, painters and laborers, carried out their trades in exceptionally dusty conditions and now carry the greatest risk of disease.

In the 50-year period prior to the mid-1970s, the asbestos industry manufactured insulation products that were installed in almost every building, home, school, ship, car and plane in America. Surprisingly, these same manufacturers knew about the long-term health risks associated with asbestos exposure, but chose to ignore the dangers. By the time the Navy became aware that asbestos products were harmful, it was too late for the thousands of veterans who became ill with asbestosis, lung cancer and mesothelioma as a result of their unnecessary exposure.

After their military service, most veterans of the asbestos era led lives outside the military. They married, built careers and raised families, never knowing that their exposure to asbestos while in the military might cruelly shorten their lives. Decades later and near retirement, many of these men and women are being denied the pleasure of living out their golden years with family and friends.

More on asbestos diseases contracted by veterans.

Diagnosis of mesothelioma.

all the above information is obtained from the following link.

http://www.mesotheliomaweb.org/clinical.htm

COMPREHENSIVE CANCER CENTERS

2009-06-14T04:39:00.000-07:00

The National Cancer Institute (NCI) has designated 40 cancer centers throughout the United States as "Comprehensive" centers. These elite centers have been recognized for their focus on scientific excellence and have dedicated themselves to the prevention, treatment and cure of cancer, including malignant mesothelioma. Following is a list of Cancer Centers by state.

For veterans wishing to be treated at a Veterans Health Administration (VA) cancer care facility, click here for a listing by state.

Alabama

UAB Comprehensive Cancer Center
1802 6th Avenue, S.
Birmingham, AL 35294
Request an appointment: (800) UAB-0933 or (205) 975-8222

Arizona

Arizona Cancer Center
1515 N. Campbell Avenue
Tucson, AZ 85724
Request an appointment: (520) 626-2900

California

City of Hope National Medical Center
1500 E. Duarte Road
Duarte, CA 91010
Request an appointment: (866) 434-HOPE (4673)

University of California, San Diego (UCSD) Moores Cancer Center
3855 Health Sciences Drive
La Jolla, CA 92093
Request an appointment: (866) 773-2703 or (858) 822-6200

UCLA Jonsson Comprehensive Cancer Center
10833 Le Conte Avenue
Los Angeles, CA 90095
Request an appointment: (800) 825-2631

USC/Norris Comprehensive Cancer Center
1441 Eastlake Avenue
Los Angeles, CA 90033
Request an appointment: (800) USC-CARE

University of California, Irvine (UCI) Chao Family Comprehensive Cancer Center
101 The City Drive, S.
Orange, CA 92868
Request an appointment: (877) UCI-DOCS (824-3627)

University of California, San Francisco (UCSF) Comprehensive Cancer Center
1600 Divisadero Street
San Francisco, CA 94115
Request an appointment: (888) 689-8273 or (415) 885-7777

Stanford University Comprehensive Cancer Center
875 Blake Wilbur Drive
Stanford, CA 94305
Request an appointment: (650) 498-6000

Colorado

University of Colorado Cancer Center
1665 N. Ursula Street
Aurora, CO 80045
Request an appointment: (800) 473-2288 or (720) 848-0300

Connecticut

Yale Cancer Center
15 York Street
New Haven, CT 06510
Request an appointment: (203) 785-4191

District of Columbia

Lombardi Comprehensive Cancer Center at Georgetown University
3800 Reservoir Road, NW
Washington, DC 20007
Request an appointment: (202) 444-2223

Florida

H. Lee Moffitt Cancer Center & Research Institute
12902 Magnolia Drive
Tampa, FL 33612
Request an appointment: (888) 860-2778 or (813) 979-3980

Illinois

Robert H. Lurie Comprehensive Cancer Center of Northwestern University
Galter Pavilion
675 N. St. Clair, 21st Floor
Chicago, IL 60611
Request an appointment: (866) LURIE-CC (587-4322)

Iowa

University of Iowa Holden Comprehensive Cancer Center
200 Hawkins Drive
Iowa City, IA 52242
Request an appointment: (319) 356-4200 8:00 am - 5:00 pm (M-F)
(800) 777-8442 or
319) 384-8442 (After hours)

Maryland

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
401 N. Broadway
Baltimore, MD 21231
Request an appointment: (410) 955-5222

Massachusetts

Dana-Farber Cancer Institute
44 Binney Street
Boston, MA 02115
Request an appointment: (877) 332-4294

Michigan

University of Michigan Comprehensive Cancer Center
1500 E. Medical Center Drive
Ann Arbor, MI 48109
Request an appointment: (800) 865-1125

Barbara Ann Karmanos Cancer Institute
4100 John R
Detroit, MI 48201
Request an appointment: (800) KARMANOS (527-6266)

Minnesota

University of Minnesota Cancer Center
425 E. River Road
Minneapolis, MN 55455
Request an appointment: (888) CANCER MN (226-2376)
(Toll Free in IA, MN, ND, SD, WI)
(612) 624-2620 (Outside Area)

Mayo Clinic Cancer Center
200 First Street, SW
Rochester, MN 55905
Request an appointment: (507) 538-3270

Missouri

Alvin J. Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine
660 S. Euclid Avenue
St. Louis, MO 63110
Request an appointment: (877) 251-6485 or (314) 747-3046

New Hampshire

Norris Cotton Cancer Center
One Medical Center Drive
Lebanon, NH 03756
Request an appointment: (603) 653-9000

New Jersey

Cancer Hospital of New Jersey at Robert Wood Johnson University Hospital
195 Little Albany Street
New Brunswick, NJ 08903
Request an appointment: (732) 828-3000

New York

Roswell Park Cancer Institute
Elm and Carlton Streets
Buffalo, NY 14263
Request an appointment: (800) ROSWELL (767-9355)

Memorial Sloan-Kettering Cancer Center
1275 York Avenue
New York, NY 10021
Request an appointment: (800) 525-2225

Herbert Irving Comprehensive Cancer Center
161 Fort Washington Avenue
New York, NY 10032
Request an appointment: (877) NYP-WELL (697-9355)

North Carolina

University of North Carolina (UNC) Lineberger Comprehensive Cancer Center
450 West Drive
Chapel Hill, NC 27599
Request an appointment: (866) 828-0270

Duke Comprehensive Cancer Center
2424 Erwin Road
Durham, NC 27705
Request an appointment: (888) ASK-DUKE (275-3853)

Wake Forest University Comprehensive Cancer Center
Medical Center Boulevard
Winston-Salem, NC 27157
Request an appointment: (800) 446-2255 or (336) 716-2255

Ohio

Case Comprehensive Cancer Center, Ireland Cancer Center
11100 Euclid Avenue
Cleveland, OH 44106
Request an appointment: (800) 641-2422

Comprehensive Cancer Center - Arthur G. James Cancer Hospital & Richard J. Solove Research Institute
300 W. 10th Avenue
Columbus, OH 43210
Request an appointment: (800) 293-5066 or (614) 293-5066

Pennsylvania

Abramson Cancer Center of the University of Pennsylvania
3400 Spruce Street
Philadelphia, PA 19104
Request an appointment: (800) 789-PENN (7366)

Fox Chase Cancer Center
333 Cottman Avenue
Philadelphia, PA 19111
Request an appointment: (215) 728-2570

University of Pittsburgh Cancer Institute
5150 Centre Avenue
Pittsburgh, PA 15232
Request an appointment: (412) 647-2811

Tennessee

Vanderbilt-Ingram Cancer Center
691 Preston Building
Nashville, TN 37232
Request an appointment: (800) 811-8480

Texas

University of Texas M. D. Anderson Cancer Center
1515 Holcombe Boulevard
Houston, TX 77030
Request an appointment: (800) 392-1611 or (713) 792-6161

Vermont

Vermont Cancer Center at the University of Vermont
89 Beaumont Avenue
Burlington, VT 05405
Request an appointment: (802) 656-4414

Washington

Fred Hutchinson Cancer Research Center
1100 Fairview Avenue, N.
Seattle, WA 98109
Request an appointment: (800) 804-8824 or (206) 288-1024

Wisconsin
University of Wisconsin Comprehensive Cancer Center
600 Highland Avenue
Madison, WI 53792
Request an appointment: (800) 622-8922

NATIONAL CANCER INSTITUTE CANCER CENTERS

UC Davis Cancer Center
4501 X Street
Sacramento, CA 95817
Request an appointment: (800) 362-5566 or (916) 734-5900

University of Chicago Hospitals
5841 S. Maryland Avenue
Chicago, IL 60637
Request an appointment: (888) UCH-0200

NYU Cancer Institute
550 First Avenue
New York, NY 10016
Request an appointment: (888) 7-NYU-MED (769-8633)

The Cleveland Clinic, Taussig Cancer Center
9500 Euclid Avenue
Cleveland, OH 44195
Request an appointment: (866) 320-4573 or (216) 444-5501

National Institutes of Health (NIH) Clinical Center, Bethesda, MD
National Insitutes of Health
10 Center Dr.
Bethesda, MD 20892
Request an appointment: 301-496-2626

Thoughts on choosing a cancer treatment.

all the above information is obtained from the following link.

http://www.mesotheliomaweb.org/cancercenters.htm

YOUR HEALTH CARE TEAM

2009-06-08T19:39:00.000-07:00

A diagnosis of mesothelioma brings with it one of the most difficult challenges you or your loved one will ever face. One of the most important things to remember, however, is that there are resources to help with every aspect of care, and that you or your loved one is at the center of the health care team that will provide help in many different forms. Remember also that in addition to your doctor you can also get a second opinion from another physician.

You, the Patient

Your role as the most important member of the team is to be a good consumer by gathering information and asking questions. Following are some easy ways to make the most of your appointment times with other members of your medical team:

Once you know the day and time of your appointment, start a list of questions you want to ask that particular team member. These questions could be about mesothelioma itself, about test results or about treatments you are undergoing or considering. It is also a good idea to write down any symptoms you may be experiencing so that they can be addressed at this time. If there is something you don’t completely understand, ask to have it explained in simpler terms. Above all, don’t be embarrassed to ask questions or request clarifications.
If possible, take along another person who can take notes, ask additional questions or record your appointment for later review. Sometimes it can be helpful to return home and play back what was discussed.
Ask for written material or brochures that can help in making treatment or care decisions . These might include information on nutrition, pain management, support groups or hospice or home care.

Other than your doctors, who could include your primary care doctor, surgeons, medical oncologists, and/or radiation oncologists, you will probably have the most contact with your nursing staff and your social worker. These medical professionals can be your best source of practical assistance when trying to navigate the waters of a mesothelioma diagnosis.

Nurses

All specialized cancer treatment facilities have nurses who are familiar with implementing the cancer treatment plan initialized by your doctor, and are trained to administer medication, monitor side effects and conduct routine tests. Whether you are a hospital inpatient or outpatient, you can benefit greatly from developing a strong working relationship with your nursing staff.

You may also request home visits by a registered nurse, if necessary. If approved by your doctor, these visits may be covered under insurance. Be sure to check with your individual insurance provider for details.

Social Workers

Social workers are a good starting point for newly diagnosed patients who are overwhelmed by their diagnosis and the many things that have to be accomplished and decided.

Some types of social workers include:

Oncology social workers specialize in assisting those diagnosed with cancer. Most cancer treatment facilities have certified oncology social workers on staff.
Clinical social workers specialize in providing services aimed at family therapy and counseling, or counseling for those coping with a serious illness.
Hospital social workers can help find resources in your local area such as home care, transportation services or support groups, and can also help you understand your diagnosis, your treatments and other care options.

Psychiatrists and Psychologists

Because of the emotional issues surrounding a mesothelioma diagnosis, some patients or their family members may benefit from the help of someone trained to deal with depression, anxiety or inability to cope. Don’t be afraid to ask for this type of help for yourself or your loved one – good emotional health is essential to quality of life.

Psychiatrists are medical doctors who specialize in providing psychotherapy and other general psychological services to their patients. They are licensed to prescribe medications such as antidepressants and sleep aids. (Related: concerns about drug addition during cancer treatment.)
Psychologists can provide many of the same services as a psychiatrist such as counseling for depression, anxiety, etc., however, they are not medical doctors. Most have PhD’s in psychology and counseling.

Nutritionists and Dietitians

Nutrition is another area that can greatly affect quality of life. Many patients lose weight because of anxiety associated with the diagnostic process, subsequent treatments or the natural progression of mesothelioma. Working with a nutritionist or dietitian as soon after diagnosis as possible is one of the most important benefits you can obtain from your health care team. These professionals can help you be sure you receive enough calories, vitamins and protein to maintain a healthy weight, as well as tailoring a program for those with concurrent health problems such as diabetes or high cholesterol. They can also suggest ways to minimize the side effects of chemotherapy or other aggressive treatment.

Most local hospitals have registered dietitians on staff, or you can ask your doctor to recommend someone in your area. As with other health care needs, check to see whether these services are covered under your insurance. If they are not, there may be community-based services available in your area at no cost.

Hospice and Home Care

Hospice care is palliative in nature, and provides comfort care by helping to control a patient’s physical symptoms as well as offering emotional and spiritual support. Although in most cases, care is provided at home, there are also hospice facilities that provide full-time care in a hospital setting. You can discuss the benefits of hospice with your doctor, nurse or social worker.
Home care provides assistance in the home with daily activities such as bathing, meal preparation or household chores. These services are usually provided by a home health aide, and may or may not be under the supervision of a nurse. Ask your doctor, nurse or social worker for Home Health Care Agencies in your area.

all the above information is obtained from the following link.

http://www.mesotheliomaweb.org/team.htm

FINDING A MESOTHELIOMA SPECIALIST

2009-06-08T01:50:00.000-07:00

The following physicians are specialists in the treatment of malignant mesothelioma. You will find links to their web sites, when available and to some of their published articles.They are listed in no particular order with no particular endorsement.

Mesothelioma is typically treated by an interdisciplinary team of doctors rather than by a single physician. You may run into professionals called oncologists, thoracic surgeons, and pulmonologists. Glossary of members of a thoracic oncology care team. More on choosing your mesothelioma doctor.

W. Roy Smythe, MD

Professor and Chairman/Department of Surgery, Texas A&M University System Health Sciences Center, Scott & White Hospital, Temple, TX
Phone: 254-724-2595

Dr. Smythe is currently accruing patients for a protocol involving extrapleural pneumonectomy and Intensity Modulated Radiation Therapy (IMRT). (Click here for an abstract of this trial).

Biography

David C. Rice, MD

Assistant Surgeon and Assistant Professor of Surgery; Director, Mesothelioma Program; Director, Minimally Invasive Surgery Program, Thoracic Surgery/The University of Texas M. D. Anderson Cancer Center, Houston, TX
Phone: (713) 794-1477

Dr. Rice is currently concluding enrollment on a Phase II trial of extrapleural pneumonectomy (EPP) followed by Intensity Modulated Radiation Therapy (IMRT). He is also anticipating the opening of a new trial of preoperative Alimta/Cisplatin, followed by EPP and IMRT.

Biography

David J. Sugarbaker, MD

Chief, Division of Thoracic Surgery/Brigham and Women's Hospital, Boston, MA Chief, Department of Surgical Services/Dana-Farber Cancer Institute, Boston, MA
Phone: (617) 732-6824

Dr. Sugarbaker believes in aggressive treatment of pleural mesothelioma. He is a proponent of tri-modal therapy; extrapleural pneumonectomy, chemotherapy and radiation.

Click here for an article by Dr. David J. Sugarbaker that appeared in the The Journal of Thoracic and Cardiovascular Surgery, January 1999 (12 pages in Adobe PDF format).

Biography

Lambros Zellos, MD, MPH

Attending Thoracic Surgeon; Clinical Co-Director of the International Mesothelioma Program/Brigham & Women's Hospital/Dana Farber Cancer Institute Harvard Medical School, Boston, MA
Phone: (617) 525-9657

Dr. Zellos is an Attending Thoracic Surgeon and the Clinical Co-Director of the International Mesothelioma Program. Dr. Zellos is a proponent of tailored multimodality therapy for each individual patient. Appropriate therapy may include surgery such as pleurectomy or extrapleural pneumonectomy with chemotherapy or radiation. Dr. Zellos has published several papers on multimodality therapy as well as methods to improve surgical techniques.

Valerie W. Rusch, FACS

Attending Thoracic Surgeon/Memorial-Sloan Kettering Cancer Center, New York, NY
Phone: (212) 639-5873

Dr. Rusch is known for the treatment of pleural mesothelioma. She has published several papers comparing pleural decortication to extrapleural pneumonectomy.

Biography

Raja M. Flores, MD

Attending Thoracic Surgeon/Memorial-Sloan Kettering Cancer Center, New York, NY
Phone: (212) 639-2806

Dr. Flores is currently the Principal Investigator on a clinical trial of neoadjuvant gemcitabine and cisplatin followed by extrapleural pneumonectomy and high dose radiation, as well as being involved in a trial of neoadjuvant Alimta/cisplatin, extrapleural pneumonectomy and high dose radiation. He has also compiled a 1,000 patient database to research areas of failure, and how to improve treatments for mesothelioma.

Biography

Paul H. Sugarbaker, MD, FACS, FRCS

Director, Surgical Oncology/Washington Cancer Institute, Washington, DC
Phone: (202) 877-3908

Dr. Sugarbaker is a specialist in the treatment of peritoneal mesothelioma using a combination of surgery, chemotherapy and radiation.

Brian W. Loggie, MD

Professor of Surgery, Creighton University Medical School; Chief, Division of Surgical Oncology; Director of Cancer Center/Creighton University Medical Center, Omaha, NE
Phone: (402) 280-4100

Dr. Loggie specializes in the treatment of peritoneal mesothelioma and peritoneal carcinomatosis. His protocol, based on eligibility, involves surgical debulking in combination with intraperitoneal heated chemotherapy.

Biography

David L. Bartlett, MD

Professor of Surgery, Chief, Division of Surgical Oncology/UPMC Cancer Pavilion, Pittsburgh, PA
Phone: (412) 692-2852

Dr. Bartlett has particular expertise in the management of advanced, complex abdominal malignancies. He also has a research interest in treating advanced carcinomas in the peritoneal cavity, including peritoneal mesothelioma.

Claire F. Verschraegen, MD

Director, Clinical Trial Office and Investigational Drug Program/Cancer Research and Treatment Center, University of New Mexico, Albuquerque, NM
Phone: (505) 272-4551

Dr. Verschraegen is currently conducting a front-line Alimta/gemcitabine trial for peritoneal mesothelioma patients. She also offers the following Phase I trials for patients who have already been treated with Alimta:

Phase I Study of Capecitabine with Cisplatin and Irinotecan in Patients with Advanced Malignancies
Phase I Study of Intravenous TZT-1027 and Gemcitabine, Administered on Day 1 and Day 8 of a Three Week Course in Patients with Advanced Solid Tumors
Phase I Study of Flavoperidol in Combination with Gemcitabine and Irinotecan in Patients with Metastatic Cancer

Biography

David P. Mason, MD

Staff Surgeon, Department of Thoracic and Cardiovascular Surgery/Cleveland Clinic Foundation, Cleveland, OH Phone: (216) 444-4053

Dr. Mason is a proponent of aggressive multimodality therapy for malignant mesothelioma. This includes extrapleural pneumonectomy, chemotherapy and radiation with Intensity Modulated Radiation Therapy (IMRT). Cleveland Clinic Foundation has a multidisciplinary Thoracic Oncology team with extensive experience and clinical trials in the management of malignant mesothelioma.

Biography

David M. Jablons, MD

Assistant Professor of Surgery Chief, General Thoracic Surgery/UCSF Mt. Zion Medical Center, San Francisco, CA Phone: (415) 885-3882

Dr. Jablons treats pleural mesothelioma with a radical pleurectomy/decortication and is researching other therapies.

Biography

Lary A. Robinson, MD

Director, Division of Cardiovascular and Thoracic Surgery Principal Thoracic Surgical Oncologist/H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL Phone: (813) 972-8412

Dr. Robinson is a member of the multidisciplinary thoracic oncology group at H. Lee Moffitt Cancer Center which evaluates and treats all stages of mesothelioma. He is also involved in clinical research programs for lung cancer and mesothelioma.

Biography

Craig W. Stevens, MD, PhD

Division Chief, Radiation Oncology/H. Lee Moffitt Cancer Center & Research Institute/Tampa, FL Phone: (813) 972-8424

Biography

Robert N. Taub, MD

Professor of Clinical Medicine, Columbia University College of Physicians and Surgeons/New York Presbyterian Hospital, New York, NY Phone: (212) 305-4076

Dr. Robert Taub is a medical oncologist who directs the Connective Tissue Oncology Program at the Herbert Irving Comprehensive Cancer Center, where there are a number of ongoing multimodality studies of patients with pleural and peritoneal mesothelioma. The Center is based at the Columbia University College of Physicians and Surgeons. Click here for a press release announcing a new multimodality study.

Biography

Daniel Sterman, MD

Assistant Professor, Department of Medicine/University of Pennsylvania Medical Center, Philadelphia, PA Phone: (215) 614-0984

Dr. Sterman is the co-author of several informative articles on treatment and clinical trials for pleural mesothelioma.

Biography

Eric Vallieres, MD

Associate Professor of Surgery, Section of General Thoracic Surgery/University of Washington Medical Center, Seattle, WA Phone: (206) 598-4477

Dr. Vallieres uses a multidisciplinary approach to thoracic malignancies and related clinical trials. Please see Medical Journal & News Articles for an article Dr. Vallieres co-authored on Induction Chemotherapy, Extra Pleural Pneumonectomy And Adjuvant Fast Neutron Radiationtherapy For Pleural Mesothelioma (Dmm).

Biography

Stephen C. Yang, MD

Chief, Division of Thoracic Surgery/Associate Professor of Surgery and Oncology/Surgical Director, Lung Transplantation Program/Director, Thoracic Oncology Program/Johns Hopkins Medical Institutions, Baltimore, MD Phone: (410) 614-3891

Biography

Mark J. Krasna, MD

Medical Director of the Cancer Institute at St. Joseph Medical Center/Towson, MD Phone: (410) 427-2220

Dr. Krasna is the former Head of the Division of Thoracic Surgery, Professor of Surgery and Associate Director for Surgical Oncology in the Greenebaum Cancer Center at the University of Maryland Medical Center.

Dr. Krasna is a leader in the development of thoracic surgery. He is the author of the first textbook on thoracoscopic surgery and has instructed surgeons worldwide on his techniques.

Biography

David H. Harpole, Jr., MD

Associate Professor of Surgery, Thoracic Oncology Program/AssistantProfessor of Pathology, Duke University Medical Center, Durham, NC Phone: (919) 668-8413

Biography

Harvey Pass, MD

Professor and Chief, Division of Thoracic Surgery and Thoracic Oncology, Department of Cardiothoracic Surgery/NYU School of Medicine and Comprehensive Cancer Center/New York, NY Phone: (212) 263-7417

Gregory P. Kalemkerian, MD

Co-Director of Thoracic Oncology/University of Michigan Comprehensive Cancer Center/Ann Arbor, MI Phone: (734) 936-5281

Dr. Kalemkerian directs the multidisciplinary thoracic oncology clinic at the University of Michigan Cancer Center, in addition to collaborating with the thoracic oncology team at Karmanos Cancer Institute, to develop novel clinical trials for mesothelioma patients.

Joseph S. Friedberg, MD

Chief of Thoracic Surgery/University of Pennsylvania at Presbyterian, Philadelphia, PA Phone: (215) 662-9195

Dr. Friedberg is currently the Principal Investigator on a trial of photodynamic therapy for pleural malignancies, and also on a trial combining Alimta/cisplatin, surgery and XRT.

Robert Cameron, MD

UCLA Medical Center, Los Angeles, CA Phone: (310) 794-7333

The list of physicians above are specialists in mesothelioma and treat it exclusively. Support Services at major cancer centers in the United States.

Sources for information on this page: medical conventions, personal contact with oncologists, websites of institutions where specialists work

all the above information is obtained from the following link.

http://www.mesotheliomaweb.org/findspc.htm#doctors

MESOTHELIOMA DIAGNOSIS QUESTIONS

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Biphasic mesothelioma tissue

Sarcomatoid mesothelioma tissue

Epithelioid mesothelioma tissue

Doctor-Patient Communication

An open line of communication between a patient and his or her physician is vital when dealing with a serious disease such as mesothelioma. There will be many questions regarding treatment, whether palliative or aggressive, choices to deal with, and life issues to confront. Being informed and proactive in your care will give you a sense of empowerment.

Although most physicians have limited time to spend with each patient at appointments, it is important to address issues as they occur and resolve them to the satisfaction of all parties involved. Initially, this may mean going to your appointment with a list of symptoms or concerns, or questions regarding specific tests that are recommended. Once mesothelioma has been diagnosed, you may have questions regarding treatment options.

Most questions from patients stem from an initial diagnosis of mesothelioma and subsequent treatment options. Following are some frequently asked questions regarding these two important issues.

What Is My Diagnosis?

There are three types of mesothelioma. Pleural mesothelioma is a cancer of the lining of the lung (pleura), peritoneal mesothelioma is a cancer of the lining of the abdominal cavity (peritoneum), and pericardial mesothelioma is a cancer of the lining surrounding the heart (pericardium). Sub-types (or cell types) of mesothelioma are epithelioid (the most common, and considered the most amenable to treatment), sarcomatous (a much more aggressive form), and biphasic or mixed (a combination of both of the other cell types).

The structural appearance of cells under the microscope determine the cell or sub-type of mesothelioma. Epithelioid is the least aggressive; sarcomatoid, the most aggressive. The biphasic or mixed cell type shows structural elements of both of the other two. More on the histologic subtypes of mesothelioma.

MESOTHELIOMA STAGES

Treatment options are often determined by the stage of mesothelioma a patient is in. There are three staging systems currently in use for pleural mesothelioma and each one measures somewhat different variables; peritoneal mesothelioma is not staged.

Staging is the term used to describe the extent of a patient's cancer, based on the primary tumor and its spread in the body. It can help the medical team plan treatment, estimate prognosis and identify clinical trials for which the patient may be eligible.

Staging is based on a knowledge of how the cancer develops, from the primary tumor, to the invasion of nearby organs and tissues, to distant spread or metastasis. Staging systems have evolved over time, and they continue to change as scientists learn more about cancer. Some staging systems cover many different types of cancer, while others focus on more specific cancers. The TNM (primary tumor, regional lymph nodes, distant metastasis) is the most common staging system for mesothelioma.

Some elements common to most staging systems are:

Location of the primary tumor.
Size and number of the tumors.
Lymph node involvement.
Cell type and tumor grade.
Metastasis.

Many cancer registries, such as the National Cancer Institute's Surveillance, Epidemiology, and End Results Program (SEER) use summary staging, a system used for all types of cancer. Summary staging groups cancer into five main categories:

In situ - cancer that is present only in the layer of cells in which it began.
Localized - cancer that is limited to the organ in which it began with no evidence of spread.
Regional - cancer that has spread from the primary site to nearby lymph nodes or organs.
Distant - cancer that has spread from the primary site to distant lymph nodes or organs.
Unknown - cases where not enough information exists to indicate stage.

Several types of testing may be used to help doctors determine stage, and to formulate a treatment plan.

Physical examinations. The doctor examines the body by looking, feeling and listening to anything out of the ordinary.
Imaging techniques. Procedures such as x-rays, CT scans, MRIs and PET scans may show the location, size of the tumor and whether the cancer has spread.
Laboratory tests. Studies of blood, urine, fluid and tissue can provide information about the cancer. Tumor markers, sometime elevated when cancer is present, may provide information.
Pathology reports. Results of the examination of tissue samples can include information about the size of the tumor(s), extension into adjacent structures, type of cells and grade of the tumor. Results of the examination of cells in fluid, such as that from a mesothelioma-related pleural effusion, may also provide information.
Surgical reports. Observations about the size and appearance of the tumor(s), lymph nodes and nearby organs.

Staging information should be provided to the patient by his doctor so that potential treatment plans can be discussed. Stage of the mesothelioma, as well as consideration of other factors such as age, health status and the patient's wishes may dictate different treatment options.

The oldest staging system and the one most often used is the Butchart System which is based mainly on the extent of primary tumor mass and divides mesotheliomas into four stages. The more recent TNM system considers variables of tumor in mass and spread, lymph node involvement, and metastasis. The Brigham System is the latest system and stages mesothelioma according to resectability (the ability to surgically remove) and lymph node involvement.

Butchart System – extent of primary tumor mass

Stage I: Mesothelioma is present in the right or left pleura and may also involve the diaphragm on the same side.
Stage II: Mesothelioma invades the chest wall or involves the esophagus, heart, or pleura on both sides. Lymph nodes in the chest may also be involved.
Stage III: Mesothelioma has penetrated through the diaphragm into the lining of the abdominal cavity or peritoneum. Lymph nodes beyond those in the chest may also be involved.
Stage IV: There is evidence of metastasis or spread through the bloodstream to other organs.

TNM System -- variables of T (tumor), N (lymph nodes), M (metastasis)

Stage I: Mesothelioma involves right or left pleura and may also have spread to the lung, pericardium, or diaphragm on the same side. Lymph nodes are not involved.
Stage II: Mesothelioma has spread from the pleura on one side to nearby lymph nodes next to the lung on the same side. It may also have spread into the lung, pericardium, or diaphragm on the same side.
Stage III: Mesothelioma is now in the chest wall, muscle, ribs, heart, esophagus, or other organs in the chest on the same side with or without spread to lymph nodes on the same side as the primary tumor.
Stage IV: Mesothelioma has spread into the lymph nodes in the chest on the side opposite the primary tumor, or extends to the pleura or lung on the opposite side, or directly extends into organs in the abdominal cavity or neck. Any distant metastases is included in this stage.

Brigham System: (variables of tumor resectability and nodal status)

Stage I: Resectable mesothelioma and no lymph node involvement
Stage II: Resectable mesothelioma but with lymph node involvement
Stage III: Unresectable mesothelioma extending into chest wall, heart, or through diaphragm, peritoneum; with or without extrathoracic lymph node involvement
Stage IV: Distant metastatic disease

How Was This Diagnosis Determined, and How Accurate Were the Tests?

Although you probably took many different tests leading up to your diagnosis, a tissue biopsy is normally the final determining factor. Following are some tests your doctor may recommend, and what may or may not be concluded from these tests.

X-rays, CT scans, and MRIs - See the imaging section for more on these techniques. On conventional x-ray film, mesothelioma appears as a markedly thickened, nodular, irregular pleural-based mass which covers the pleural surface. The tumor often encompasses the involved lung, but is only rarely seen bilaterally. Chest wall, diaphragmatic, and mediastinal invasion may be seen in advanced cases. Moderate to large pleural effusion is often noted on the affected side. On CT scan, pleural thickening greater than 1 cm can be identified in over 90% of cases; thickening which extends into the interlobular fissure is seen in 85% of cases. Absence of pleural thickening does not preclude mesothelioma, and at times, the only CT finding is that of pleural effusion.
Cytology - Testing of the pleural fluid for malignant cells is considered to have limited value in diagnosing mesothelioma. Negative or inconclusive readings account for nearly 85% of all fluid tested. Even with a positive fluid report, many doctors prefer to perform a confirming tissue biopsy as long as it does not compromise the patient's health.
Needle Biopsy - In this test, done under local anesthetic, a large hollow needle is inserted through the skin and into the chest cavity. The needle is then rotated, and as it is taken out, tissue samples are collected. Because of the small sample size of the tissue, this type of biopsy is considered to be only 25-60% accurate in diagnosing mesothelioma. Because tumor seeding may occur along the needle tract in approximately 20% of patients, local radiation therapy may be used in conjunction with this test.
Open biopsy - This type of biopsy is considered to be the most accurate for mesothelioma diagnosis, and is the procedure of choice because it affords the pathologist a larger tissue sample.. It is done in a hospital under general anesthetic. As with a needle biopsy, local radiation may be used because of the possibility of tumor seeding.

Can I Be Treated by the Doctor Who Diagnosed My Mesothelioma?

If the doctor who diagnosed your mesothelioma is your primary physician, he will most likely refer you to a local oncologist for treatment. The oncologist may offer what he or she feels are the best treatment options, or, if their knowledge of this disease is limited, may suggest you seek out a doctor who specializes in mesothelioma. Most often these physicians are located at larger, teaching hospitals such as those listed in the Comprehensive Cancer Center Section. These facilities are ranked as state-of-the-art cancer centers, and are highly respected for their patient care and innovative cancer treatments. If your choice of treatment involves a radical surgical procedure or a clinical trial involving new, as yet unproven drugs, these facilities may be best for you. If your treatment involves an already-approved, standard form of chemotherapy, this can be carried out locally.

What Treatment Options Will I Be Offered?

Treatment options may vary according to the age and over-all health of the patient, and the extent of the disease. It is important to be informed of all available options for your particular case, so that you can make decision on the option you feel most comfortable with. Surgery, chemotherapy, and clinical trials, as well as new approaches such as photodynamic therapy, immunotherapy, and gene therapy may be offered. Speak openly with your doctor regarding suggested procedures. Questions may include:

Why is this procedure best for me?
What does the procedure entail?
What are the advantages/disadvantages of this treatment (i.e, will this procedure limit my eligibility for other treatments)?
What are the possible risks or adverse side effects?
What are the response, survival, and mortality rates associated with this procedure?

Is Palliative Treatment an Option?

In some circumstances, age, contributing health problems, or advanced disease may make aggressive treatment impossible. In these cases, palliative care (that which treats the symptoms, but not the disease itself) may be appropriate. If you opt for palliative care, it is doubly important to communicate fully with your doctor. Many symptoms of mesothelioma can be alleviated or substantially lessened if you are completely open with your doctor. Each time you have an appointment, tell your doctor how you feel, what discomfort you are experiencing, and your level of pain. A good doctor should be willing to address your questions and concerns.

Check our mesothelioma glossary.

MESOTHELIOMA DIAGNOSIS

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How is mesothelioma diagnosed?

A diagnosis of mesothelioma is most often obtained with careful assessment of clinical and radiological findings in addition to a confirming tissue biopsy. (Learn about typical mesothelioma symptoms.) A review of the patient's medical history, including history of asbestos exposure is taken, followed by a complete physical examination, x-rays of the chest or abdomen, and lung function tests. A CT scan or MRI may also be done at this time. If any of these preliminary tests prove suspicious for mesothelioma; a biopsy is necessary to confirm this diagnosis.

Imaging Techniques and Their Value in Diagnosing and Assessing Mesothelioma

There are several imaging techniques which may prove useful when mesothelioma is suspected due to the presence of pleural effusion combined with a history of occupational or secondary asbestos exposure. While these imaging techniques can be valuable in assessing the possibility of the cancer, definitive diagnosis is still most often established through fluid diagnosis or tissue biopsy.

Some of the most commonly used imaging methods include:

X-ray

A chest x-ray can reveal pleural effusion (fluid build-up) which is confined to either the right (60%) or left (40%) lung. On occasion, a mass may be seen. Signs of prior non-cancerous asbestos disease, such as pleural plaques or pleural calcification, or scarring due to asbestosis may also be noted.

Computed Tomography (CT)

CT scans are also able to define pleural effusion, as well as pleural thickening, pleural calcification, thickening of interlobular fissures, or possible chest wall invasion. CT, however, is not able to differentiate between changes associated with benign asbestos disease (pleural disease), or differentiate between adenocarcinoma of the lung wh
ich may have spread to the pleura verses mesothelioma. CT scans may also be valuable in guiding fine needle aspiration of pleural masses for tissue diagnosis.

Magnetic Resonance Imaging (MRI)

MRI scans are most often used to determine the extent of tumor prior to aggressive treatment. Because they provide images in multiple planes, they are better able to identify tumors as opposed to normal structures. They are also more accurate than CT scans in assessing enlargement of the mediastinal lymph nodes (those lymph nodes which lie between the two lungs), as well as a clear diaphragmatic surface, both of which play an important role in surgical candidacy.

Positron Emission Tomography (PET)

PET imaging is now becoming an important part of the diagnosis and evaluation of mesothelioma. While PET scans are more expensive than other types of imaging, and are not always covered under insurance, they are now considered to be the most diagnostic of tumor sites, as well as the most superior in determining the staging of mesothelioma. Further explanation of PET scans.

CT/PET

For patients who may be candidates for aggressive multimodality treatment (surgery, chemotherapy and radiation), accurate clinical staging is extremely important. Integrated CT/PET imaging provides a relatively new tool in this respect, and has become the imaging technique of choice for determining surgical eligibility. By combining the benefits of CT and PET (anatomic and metabolic information) into a single scan, this technology can more accurately determine the stage of the cancer, and can help identify the best treatment option for the patient. Read about a study of CT-PET imaging in preoperative evaluation of patients with malignant pleural mesothelioma.

A needle biopsy of the mass, or the removal and examination of the fluid surrounding the lung, may be used for diagnosis, however, because these samples are sometimes inadequate as far as determining cell type (epithelial, sarcomatous, or mixed) or because of the unreliability of fluid diagnosis, open pleural biopsy may be recommended. In a pleural biopsy procedure, a surgeon will make a small incision through the chest wall and insert a thin, lighted tube called a thoracoscope into the chest between two ribs. He will then remove a sample of tissue to be reviewed under a microscope by a pathologist. In a peritoneal biopsy, the doctor makes a small incision in the abdomen and inserts a peritoneoscope into the abdominal cavity.

Once mesothelioma is suspected through imaging tests, it is confirmed by pathological examination. Tissue is removed, put under the microscope, and a pathologist makes a definitive diagnosis, and issues a pathology report. This is the end of a process that usually begins with symptoms that send most people to the doctor: a fluid build-up or pleural effusions, shortness of breath, pain in the chest, or pain or swelling in the abdomen. The doctor may order an x-ray or CT scan of the chest or abdomen. If further examination is warranted, the following tests may be done:

Video-Assisted Thoracoscopic Surgery (VATS)

Over the past decade, the use of video-assisted thoracic surgery (VATS) has become one of the most widely used tools in the diagnosis of mesothelioma. Biopsies of the pleural lining, nodules, masses and pleural fluid can now easily be obtained using this minimally invasive procedure, and other therapies such as pleurodesis (talc) for pleural effusions can be done concurrently.While the patient is under general anesthesia, several small incisions or “ports” are made through the chest wall. The surgeon then inserts a small camera, via a scope, into one incision, and other surgical instruments used to retrieve tissue samples into the other incisions. By looking at a video screen showing the camera images, the surgeon is able to complete whatever procedures are necessary

In many cases, this video-assisted technique is able to replace thoracotomy, which requires a much larger incision to gain access to the chest cavity, and because it is minimally invasive, the patient most often has less post-operative pain and a potentially shorter recovery period.

Thoracoscopy

For pleural mesothelioma the doctor may look inside the chest cavity with a special instrument called a thoracoscope. A cut will be made through the chest wall and the thoracoscope will be put into the chest between two ribs. This test is usually done in a hospital with a local anesthetic or painkiller.

If fluid has collected in your chest, your doctor may drain the fluid out of your body by putting a needle into your chest and use gentle suction to remove the fluid. This is called thoracentesis.

Peritoneoscopy

For peritoneal mesothelioma the doctor may also look inside the abdomen with a special tool called a peritoneoscope. The peritoneoscope is put into an opening made in the abdomen. This test is usually done in the hospital under a local anesthetic.

If fluid has collected in your abdomen, your doctor may drain the fluid out of your body by putting a needle into your abdomen and using gentle suction to remove the fluid. This process is called paracentesis.

Biopsy

If abnormal tissue is found, the doctor will need to cut out a small piece and have it looked at under a microscope. This is usually done during the thoracoscopy or peritoneoscopy, but can be done during surgery. More on needle biopsies.

Pathology and The Role of Pathologists in the Diagnostic Process

Pathology, or the scientific study of cells, tissue, or fluid taken from the body is an integral part of a mesothelioma diagnosis. Most hospitals have their own pathology labs staffed by board-certified pathologists and licensed technologists. The importance of pathological diagnosis can not be underestimated, since the course of treatment is dependent upon an accurate diagnosis.

To make a diagnosis, pathologists examine tissue under a microscope, and based on established criteria, make a determination of benign vs. malignant cells. (More on biopsy tissue processing.) Subsequently, the type of cancer is determined. Although most pathologists have a general expertise of various diseases, a small number acquire training in a subspecialty, such as mesothelioma. These are physicians who have received world-wide recognition as premier experts, and have achieved high acclaim for their research, published articles and abstracts, and teaching. For a list of expert pathologists in the field of mesothelioma diagnosis, please call the MW toll free at 1-877-367-6376 or fill in the form at the bottom of this page specifying your request.

Knowing the stage is a factor in helping the doctor form a treatment plan. Mesothelioma is considered localized if the cancer is confined to the pleura, or advanced if it has spread beyond the pleura to other parts of the body such as the lungs, chest wall, abdominal cavity, or lymph nodes.

Immunohistochemical Markers for Mesothelioma

A diagnosis of any specific type of cancer often means ruling out other cancers in the process. This is true in the case of mesothelioma, where the most common “differential diagnosis” is that of adenocarcinoma versus mesothelioma.

During the biopsy procedure, the surgeon removes tissue samples to be sent to the laboratory. In the lab, slides are produced and then viewed and analyzed by a pathologist. These tissue specimens arrive at the lab with a request form that details patient information and history along with a description of the site in the body from which the specimen was obtained. Each individual specimen is numbered for each patient.

The pathologist then does a “gross examination” which consists of describing the tissue, and then placing it in a plastic cassette. The cassettes are then placed in a fixative that preserves the tissue permanently. Once the tissue has been fixed, it is processed into a paraffin block that will allow the pathologist to slice off thin microscopic sections that will then be stained to determine the patient’s diagnosis.

Immunohistochemistry is defined as “a method of analyzing and identifying cell types based on the binding of antibodies to specific components of the cell”. It is this process that helps diagnose mesothelioma versus adenocarcinoma (or other types of cancer).

Early on, the “markers” which helped distinguish mesothelioma from adenocarcinoma were “negative markers”; those expressed in adenocarcinomas, but not in mesotheliomas. This made it more difficult to confirm a diagnosis, because pathologists were dealing with the absence of, rather than the presence of certain markers. Some of these markers, which are normally “positive” in an adenocarcinoma diagnosis and “negative” in a mesothelioma diagnosis, are carcinoembryonic antigen (CEA), CD 15 (LeuM1), epithelial glycoprotein (Bg8), tumor glycoprotein (BerEp4) and tumor glycoprotein (MOC-31).

In more recent years, “positive markers” expressed by mesotheliomas have come to the forefront. Some of the markers which are normally “positive” in mesotheliomas and “negative” in adenocarcincomas are calretinin, cytokeratin 5, HBME-1, mesothelin, N-cadherin, thrombomodulin, vimentin and Wilm’s tumor gene product (WT-1).

It is important to remember that while the above markers are commonly used to help diagnose the epithelial sub-type of mesothelioma, that they may also be expressed in other types of cancer, and may not necessarily apply to the bi-phasic or sarcomatoid sub-types of mesothelioma. Your doctor can always contact a more specialized lab if he/she feels your diagnosis is in any way inconclusive.

all the above information is obtained from the following link.

http://www.mesotheliomaweb.org/diagnosis.htm

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MESOTHELIOMA SYMPTOMS

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The early symptoms of mesothelioma are generally non-specific, and may lead to a delay in diagnosis. Sometimes resembling viral pneumonia, pleural mesothelioma patients may present with shortness of breath, chest pain and/or persistent cough; some patients show no symptoms at all. A chest x-ray may show a build-up of fluid or pleural effusion (discussed below). The right lung is affected 60% of the time, with involvement of both lungs being seen in approximately 5% of patients at the time of diagnosis. Less common symptoms of pleural mesothelioma include fever, night sweats and weight loss. Symptoms of peritoneal mesothelioma may include pain or swelling in the abdomen due to a build-up of fluid, nausea, weight loss, bowel obstruction, anemia or swelling of the feet.

PLEASE KEEP IN MIND THAT THESE SYMPTOMS MAY BE CAUSED BY MESOTHELIOMA OR BY OTHER LESS SERIOUS CONDITIONS. ONLY A DOCTOR CAN MAKE A DEFINITIVE DIAGNOSIS.

Information on the symptoms, diagnosis, staging, and treatment of peritoneal mesothelioma.

Information on the symptoms, diagnosis, staging, and treatment of pleural mesothelioma.

Pleural Effusion

One of the most common symptoms of mesothelioma is a pleural effusion, or an accumulation of fluid between the parietal pleura (the pleura covering the chest wall and diaphragm) and the visceral pleura (the pleura covering the lungs). Both of these membranes are covered with mesothelial cells which, under normal conditions, produce a small amount of fluid that acts as a lubricant between the chest wall and the lung. Any excess fluid is absorbed by blood and lymph vessels maintaining a balance. When too much fluid forms, the result is an effusion.

Types

Pleural effusion is broken down into two categories, transudates and exudates. A transudate is a clear fluid that forms not because the pleural surfaces are diseased, but because of an imbalance between the normal production and removal of the fluid. The most common cause of transudative fluid is congestive heart failure. An exudate, which is often cloudy and contains many cells and proteins, results from disease of the pleura itself, and is common to mesothelioma. To determine whether a fluid is a transudate or exudate, a diagnostic thoracentesis, in which a needle or catheter is used to obtain a fluid sample, may be conducted.

Symptoms

As the volume of fluid increases, shortness of breath, known as "dyspnea", and sometimes pain, ranging from mild to stabbing, may occur. Some patients may experience a dry cough. When the doctor listens to the patient’s chest with a stethoscope, normal breath sounds are muted, and tapping on the chest will reveal dull rather than hollow sounds.

Diagnosis

Diagnosis of pleural effusion is usually accomplished with a simple chest x-ray, although CT scans or ultrasound may also be used. A special x-ray technique, called a lateral decubitus film, may be used to detect smaller effusions or to enable the physician to estimate of the amount of fluid present. If the underlying cause of the effusion is readily apparent (such as in the case of severe congestive heart failure), sampling of the fluid may not be necessary, however, because pleural effusion may be symptomatic of a number of disease processes from benign to malignant, a fluid sample is generally taken. Diagnostic thoracentesis, in which cells are extracted from the pleural cavity, is commonly done when the possibility of mesothelioma exists, however, in up to 85% of cases, the fluid tests negative or inconclusive even though cancer is present. It is ultimately a needle biopsy of the pleura (lining of the lung) or an open surgical biopsy which confirms a mesothelioma diagnosis.

Treatment

Pleural effusion caused by heart failure or infection can usually be resolved by directing treatment at the cause, however, when testing has realized no diagnosis, and fluid continues to build or recur, doctors may recommend chest tube drainage and chemical pleurodesis. Chemical pleurodesis is a technique in which a sclerosing agent is used to abrade the pleural surfaces producing an adhesion between the parietal and visceral pleurae. This will prevent further effusion by eliminating the pleural space. Talc appears to be the most effective agent for pleurodesis, with a success rate of nearly 95%. It is highly effective when administered by either poudrage or slurry. Poudrage is the most widely used method of instilling talc into the pleural space. Before spraying the talc, the medical team removes all pleural fluid to completely collapse the lung. After the talc is administered, they inspect the pleural cavity to be sure the talc has been evenly distributed over the pleural surface. Some doctors prefer to use talc mixed with saline solution which forms a wet slurry that can roll around the pleural cavity.

Fatigue in Mesothelioma Patients

Mesothelioma Pain

all the above information is obtained from the following link.

http://www.mesotheliomaweb.org/symptoms.htm

MESOTHELIOMA COMMON QUESTIONS

2009-06-04T20:11:00.000-07:00

What is Mesothelioma?

The National Cancer Institute states that: "Malignant mesothelioma, a rare form of cancer, is a disease in which cancer (malignant) cells are found in the sac lining the chest (the pleura), the lining of the abdominal cavity (the peritoneum) or the lining around the heart (the pericardium)."

What is peritoneal mesothelioma?

Peritoneal mesothelioma is a cancer of the lining of the abdominal cavity. This form of cancer makes up approximately one-fifth to one-third of the total number of mesothelioma cases diagnosed. More on peritoneal mesothelioma.

How do you get malignant mesothelioma?

Most people with malignant mesothelioma have worked on jobs where they breathed asbestos. Others have been exposed to asbestos in a household environment, often without knowing it. More about the different ways in which people have been exposed to asbestos.

How much exposure does it take to get the disease?

An exposure of as little as one or two months can result in mesothelioma 30 or 40 years later. Mesothelioma cause.

How long does it take after exposure for the disease to show up?

People exposed in the 1940s, 50s, 60s, and 70s are now being diagnosed with mesothelioma because of the long latency period of asbestos disease.

What is the prognosis for malignant mesothelioma?

Like most cancers, the prognosis for this disease often depends on how early it is diagnosed and how aggressively it is treated. Click on Treatment Options to find out more about traditional and new approaches.

Is there any promising research or are there promising drugs for mesothelioma?

Research is being conducted at various cancer centers all over the United States as well as by pharmaceutical companies. To find more about these studies, click on Clinical Trials. To read abstracts of the latest journal articles on mesothelioma research and to access these articles, click on Medical Journal Articles; or Mesothelioma News for news articles. A recent study of Alimta showed patients living much longer with Alitma than other chemotherapy drugs.

Where can I find information on living with mesothelioma?

Mesothelioma Aid is a good website for resource for families dealing with mesothelioma. It includes advice and referrals to other resources for coping with cancer, caregiving, financial challenges, and support groups. Alternatively, contact us here at Mesothelioma Web for help finding resouces for living with this disease.

What kinds of other resources are available for people with malignant mesothelioma?

There are numerous cancer web sites, some specific to mesothelioma. Because they are often difficult to locate, we have listed some relevant medical sites under Leading Cancer Links. We are always on the lookout for more so check our site often.

all the above information is obtained from the following link.

http://www.mesotheliomaweb.org/mesothelioma.htm#about

MESOTHELIOMA TREATMENT OPTIONS

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The treatment program for mesothelioma depends on many factors, including: the stage of the cancer, where the cancer is, how far the cancer has spread, how the cancer cells look under the microscope and the patient’s age and desires.

TIME MATTERS

People diagnosed with this disease are often told the expected survival rate is only eight to twelve months. However, specialists in treating malignant mesothelioma at the leading cancer centers often have better statistics.

For instance, the five-year survival rate has approached 40% for selected patients of Dr. David Sugarbaker at Brigham and Women’s Center in Boston. To qualify for Dr. Sugarbaker’s treatment you must meet certain criteria. One of them is being in the early stages of the disease, so time is of the essence. To find out more about Dr. Sugarbaker and other physicians and cancer centers specializing in mesothelioma click on Finding Specialists.

Keeping track of your medical treatment is useful and a personal medical records file can help.

TRADITIONAL CARE

There are three traditional kinds of treatment for patients with malignant mesothelioma:

Surgery (taking out the cancer)
Chemotherapy (using drugs to fight the cancer)
Radiation Therapy (using high-dose x-rays or other high-energy rays to kill cancer cells)

Often two or more of these are combined in the course of treatment. (NEW! Click here for the newest trial of trimodal lung-sparing treatment for pleural mesothelioma: The Columbia Protocol.)

MESOMARK BLOOD TEST

In January 2007, the Food and Drug Administration (FDA) approved the MESOMARK assay to help monitor response to treatment in epithelial and bi-phasic malignant mesothelioma patients. A specific protein, or biomarker, called Soluble Mesothelin-Related Peptide (SMRP), may be released into the blood by mesothelioma cancer cells. By measuring the amount of SMRP in a blood sample, doctors may be able to better monitor a patient's progress. Based on the limited amount of data currently available, use of this test may be beneficial, but effectiveness has not been determined at this time. The MESOMARK blood test has NOT yet been approved for the early diagnosis of mesothelioma.

This test has been approved as a Humanitarian Use Device (HUD), meaning that physicians must follow certain procedures to qualify their patients for testing. Once the physician is certified, informational brochures will be sent to be distributed to each applicable patient.

Those wishing to take part in

MESOMARK testing will be asked to provide one or more samples of blood. The blood samples will then be sent to a national reference laboratory for testing. In conjunction with other clinical and laboratory data obtained by your doctor, decisions regarding your treatment and care may be simplified. You may discontinue testing at any time.

The costs associated with the MESOMARK blood test may not be covered under health insurance, therefore, you may be required to pay all or part of the costs out of pocket. It is recommended that you check with your insurance carrier to determine whether coverage is available under your policy.

SURGERY

Diagnostic Procedures

As previously mentioned in the "Symptoms" section of this website, a diagnosis of mesothelioma from fluid is many times inconclusive. Given this fact, diagnostic surgery becomes a necessary next step in confirming and staging mesothelioma.

Thoracoscopy enables a physician to evaluate the pleural cavity and to conduct multiple tissue biopsies under direct vision. In up to 98% of cases, a definitive diagnosis can be obtained. Often, chemical pleurodesis aimed at relieving the accumulation of fluid in the intrapleural space, can be accomplished during the same procedure. It is also possible to gauge the extent of the tumor, and make a determination of surgical resectability. While less invasive than an open biopsy, it can only be performed on patients where tumor has not obliterated the pleural space.

VATS, or video-assisted thoracic surgery is an alternative to thoracoscopy, although because of its more invasive nature, concerns of tumor seeding increase. By utilizing small incisions, the physician can view the pleural spacewith the assistance of a camera, and obtain sufficient tissue samples for analysis by a pathologist. Extent of the tumor (i.e., pleural involvement, chest wall invasion) may also determined, and recommendation as to the type of debulking procedure necessary can be made at this time.

Mediastinoscopy is sometimes used as an aid in staging extent of disease when enlarged nodes are seen using imaging techniques.

Laproscopy is used in mesothelioma patients in cases where imaging techniques suggest possible invasion of the tumor through the diaphragm. This information can be important in evaluating a patient for potential pleurectomy or extrapleural pneumonectomy.

Palliative Procedures

Palliative surgical procedures are those which treat a symptom of mesothelioma, without aggressively treating the disease itself.

Chest Tube Drainage and Pleurodesis is considered the most common of palliative treatments. Fluid build-up, or pleural effusion, is most often the first symptom which will prompt mesothelioma patients to seek medical attention. Once this effusion has occurred, it is many times persistent, returning rapidly after initial thoracentesis (draining of the fluid). In order to eliminate this problem, the pleural space must be closed. This is accomplished by use of a talc slurry or other sclerosing agent which produces an adhesion.

Thoracoscopy and Pleurodesis is done in conjunction with VATS using a powdered form of talc versus talc slurry. Both this and chest tube drainage and pleurodesis will be only effective if there is no tumor encasing the lung which restricts its expansion.

Pleuroperitoneal Shunt plays a limited role in palliation for several reasons. It involves placement of a catheter run under the skin from the pleural to the peritoneal cavity. Obstruction of the catheter and possible seeding of the tumor into the abdominal cavity may be concerns.

Pleurectomy, used as a palliative procedure, may be performed where more extensive surgery is not an option. In these cases, it is understood that all visible or gross tumor will not be removed. It is considered the most effective means of controlling pleural effusion in cases where the lung's expansion is restricted by disease.

Potentially Curative Procedures

These procedures are performed with "curative intent". Their goal is removal of all gross disease, with the knowledge that microscopic disease will most likely remain. Adjuvant therapy (another form of treatment in addition to the primary therapy) is typically aimed at eliminating residual disease.

For Pleural Mesothelioma:

Pleurectomy/Decortication is usually performed on patients with early stage disease (Stage I and selected Stage II), and attempts to remove all gross tumor. If it is found that all tumor can not be removed without removing the lung, this may be done at the same time and is called pneumonectomy.

Extrapleural Pneumonectomy is considerably more radical than other surgical approaches, and should be carried out by surgeons with great expertise in evaluating patients and performing the procedure itself. (See Finding Specialists.) Because in the past surgery alone has failed to effect a cure, or even to help prolong life for any extended period of time, it is currently being combined with traditional chemotherapy and/or radiation, or other new approaches such as gene therapy, immunotherapy or photodynamic therapy.

General Patient Selection Criteria for Extrapleural Pneumonectomy

Extrapleural pneumonectomy is a serious operation, and doctors experienced in this procedure choose their patients carefully. It is up to each individual surgeon to advise the patient on its feasibility and to conduct whatever tests he/she feel are necessary to optimize the patient's chances for survival and recovery. Following is a general list of patient selection criteria. This list may not be all inclusive, and may vary according to the preference of the surgeon.

Karnofsky Performance Status score of >70. This score relates to what symptoms of disease the patient may be experiencing and how well they are able to conduct their daily activities. Some surgeons may require a higher performance status than others.
Adequate renal (kidney) and liver function tests; no significant kidney or liver disease.
Normal cardiac function per electrocardiogram and echocardiography.
Adequate pulmonary function to tolerate the surgery.
Disease limited to the ipsilateral hemithorax (the same side of the chest in which the mesothelioma is located) with no penetration of the diaphragm, extension to the heart or extensive involvement of the chest wall.
Age of the patient is taken into consideration, but may not be as important as their overall status.

Surgeries of this nature should always be done with a complete understanding of the possible benefits and risks involved. If you are considering surgery as a treatment option, speak openly with your doctor about your concerns, and be sure all of your questions are answered to your satisfaction.

For Peritoneal Mesothelioma:

Cytoreductive Surgery is aimed at removing all or nearly all of the gross or visible tumor in the peritoneal cavity. In order to treat any remaining cancer cells, Intra-Peritoneal Hyperthermic (heated) Chemotherapy (IPHC) is then delivered to the abdominal cavity. The type of chemotherapy drug used may vary according to the physician’s preference. Click here for more on treatment of peritoneal mesothelioma.

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CHEMOTHERAPY

Chemotherapy is defined as the treatment of cancer using chemical substances. When cancer occurs, abnormal cells continue to divide uncontrolled. Anticancer, or chemotherapy drugs, work to destroy cancer cells by preventing them from multiplying. Read more on types of chemotherapy medicines.

Purposes of Chemotherapy

Chemotherapy may be used to achieve different goals, depending on the stage of the cancer at the time of diagnosis and the age and health of the patient. Since chemotherapy for mesothelioma is not considered "curative", the goal is:

To control the cancer by stopping its spread or slowing its growth.
To shrink tumors prior to other treatments, such as surgery. This is called neoadjuvant chemotherapy.
To destroy microscopic disease which may remain after surgery. This is called adjuvant chemotherapy.
To relieve symptoms, such as pain. This is called palliative chemotherapy, and is given in cases when a drastic reduction in the tumor is not expected.

The most common use for chemotherapy in mesothelioma patients, is as an option for those who are not surgical candidates, however, various cancer centers are now conducting trials using the neoadjuvant approach. Alimta (pemetrexed) is a drug approved by the Food and Drug Administration (FDA) for use with Cisplatin in the treatment of patients with malignant pleural mesothelioma whose disease is either unresectable or who are not candidates for curative surgery. Alimta is the first drug approval specific to mesothelioma.

The Alimta/Cisplatin chemotherapy regimen is the first Food and Drug Administration (FDA) approved treatment specifically for malignant pleural mesothelioma. This is currently considered the most effective first-line treatment for mesothelioma patients who are not surgical candidates. A multi-targeted antifolate drug, Alimta works by blocking the enzymes necessary for DNA copying and cell division. During the clinical trial process, Alimta/Cisplatin improved median survival for pleural mesothelioma patients by approximately three months over treatment with Cisplatin as a single agent. Eli Lilly's information on treatment with Alimta.

As with any medical treatment, it is important to discuss the use of Alimta with your doctor. This conversation should include all pertinent information regarding effectiveness, administration and possible side effects of the drug combination. It is also important to begin vitamin supplementation of B12 by injection during the week prior to treatment (to be repeated every 9 weeks), and folic acid by mouth daily (to be continued until 21 days after the last cycle of Alimta). Additionally, you will be given an oral steroid medication to minimize the risk of skin rash or other possible side effects. Your doctor will have information on the correct dosages of each medication. Be sure to tell your doctor of any other medications you are taking (including non-prescription drugs) so he may be aware of any adverse interactions.

Alimta/Cisplatin is administered to patients on an outpatient basis every 21 days. This cycle of treatment involves a 10-minute IV infusion of Alimta followed by a 2 hour infusion of Cisplatin. How many cycles of treatment you receive will be dependent on your response rate to the drug (regression of the tumor or halt to progression of the disease) and the side effects you might experience.

Side effects of Alimta/Cisplatin are mild to moderate for most mesothelioma patients, i.e., nausea, vomiting and fatigue, and can usually be managed by your doctor. For some patients, however, side effects may be debilitating, and may require a decrease in dosage or removal from the program. All potential side effects should be mentioned to your doctor. Never assume any complaint is minor.

Administration of Chemotherapy

The most common way to administer chemotherapy is intravenously, or through a vein. A thin needle is inserted into a vein in the hand or in the lower arm. Intravenous administration of drugs allows for rapid entry into the blood stream. Drugs may also be delivered via catheters and/or ports.

Catheters are soft, thin, flexible tubes placed into a large vein in the body. They remain in place for as long as they are needed.
The catheter may sometimes be attached to a port, a small round plastic or metal disc placed under the skin on the chest. Ports also remain in place for as long as necessary.
Intraperitoneal chemotherapy may also be delivered through a catheter or a port. The catheter is inserted through the abdominal wall. Chemotherapy drugs can then be infused directly into the abdominal cavity. Ports may also be placed under the skin of the abdominal wall and the catheter tunneled between the skin and muscle into the peritoneum.

Side Effects of Chemotherapy

Cancer cells grow and divide more rapidly than normal cells, but some normal cells also multiply quickly, particularly those in the digestive tract, reproduction system, and hair follicles. It is the damage done to normal cells that causes side effects. The type of side effects you might experience and how severe they are, depend on the type of chemotherapy you are receiving, the dosage given and how your own body reacts. Before beginning any chemotherapy treatment, you will be asked to sign a consent form. Before signing the form, be sure your doctor informs you of all the facts regarding the treatment he/she will be administering, including information about the particular drug or combination of drugs to be used, the possible risks or side effects (including nausea and vomiting and peripheral neuropathy), the number of treatments you will receive and how often, and whether it will be given during a hospital stay or on an outpatient basis. More on vomiting and nausea from chemotherapy. More on peripheral neuropathy. More on anti-nausea treatment for chemotherapy patients.

Click here if you are interested in learning more about chemotherapy for mesothelioma and the types of questions you should ask your doctor.

Chemotherapy Schedules

How often you will receive chemotherapy will be determined by your doctor, taking into consideration factors such as the stage of your cancer, the types of drugs you receive, the anticipated toxicities of the drugs and the time necessary for your body to recover from these toxicities. The doctor may also consider whether the goal of the chemotherapy is to control the growth of the cancer, or to ease symptoms associated with the disease.

In general, chemotherapy treatment is administered in "cycles" — a "cycle" being defined as a period of treatment followed by a period of rest. This cycle allows the cancer cells to be attacked by the drugs, and then allows the body's normal cells time to recover. The combination of drugs used, the length of time to administer the drugs, how often they should be repeated and the number of cycles recommended have been analyzed throughly in clinical trials. For mesothelioma patients, the "standard" treatment is a combination of Alimta and cisplatin, administered IV, with a 10 minute infusion of Alimta followed by two hours of cisplatin, given in 21 day cycles. Modifications to this schedule may be made according to what your doctor feels is appropriate in your particular case.

The number of treatment cycles, or the length of time between the beginning and end of chemotherapy may vary, however in general, 3 to 4 cycles of treatment are given before response is evaluated; 2 to 3 cycles are considered a minimum to assess for effectiveness. After response to the treatment has been determined, the following criteria will be used to decide whether chemotherapy should continue:

If there is shrinkage of the tumor, or the disease is kept stable, chemotherapy may be continued for as long as it can be tolerated and there is no disease progression.
If there is continued disease progression, chemotherapy will be stopped, and the patient will be given alternative options.

The goal of setting a chemotherapy schedule is to make treatment as effective, timely and trouble-free as possible, but while the drugs are working to kill cancer cells, they may also affect healthy cells causing side effects. One of the most common side effects, and one your doctor will monitor carefully, is a chemotherapy-induced low white blood cell count (neutropenia) which means your immune system is weakened, therefore leaving you more prone to infection. While this side effect is anticipated when someone is undergoing chemotherapy, it can cause delays in your treatment schedule, or changes in the dosage of the drugs you will receive. Click here for more on understanding your blood counts.

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Note to Patients:

Chemotherapy treatment should be a cooperative effort between you and your doctor. The interaction that takes place is important to your health. It will not only help you feel better, but will also address any potential problems with miscommunication.

It is necessary for your doctor to be aware of any side effects which may result from your chemotherapy treatment.

These may include:

Fever of, or greater than 101 degrees
Nausea or vomiting
Diarrhea or constipation
Fatigue
Tingling or numbness in the fingers or toes
Ringing in the ears
Bruises or rashes
Sores in the mouth or throat

2. Taking other medication of any kind can alter the effects of chemotherapy or cause undesirable interactions.
Be sure you report all over-the-counter and prescribed medicines to your doctor. Don’t take aspirin unless it has been approved by your doctor. Ask your pharmacist if aspirin is contained in any drugs you plan to purchase.

3. Take extra care with your daily health.

Try to maintain a stable weight by eating a healthy diet and drinking plenty of fluids. If your stomach is upset, ask your doctor for helpful hints or work with a nutritionist who can tailor a program to your needs. Brush your teeth after every meal, or if you can’t brush, rinse your mouth thoroughly with water.

Stay away from people who have colds or the flu. Chemotherapy can compromise your immune system and lower your resistance to germs. Make sure you keep appointments for blood work – these tests help your doctor monitor your health.

4. Be open about your feelings regarding your treatment.

It is normal to feel sad, angry or afraid, however, letting these emotions get out of control can be detrimental to your overall well-being. Seek out the help of family, friends, your doctor, a counselor or a support group.

RADIATION THERAPY

Radiation therapy, also called radiotherapy, treats cancer by using penetrating beams of high energy or streams of particles called radiation. In treating mesothelioma, radiation may be used aggressively in combination with surgery, or palliatively to control symptoms.

In an aggressive combined modality approach, radiation is used to attack microscopic or residual disease remaining in the chest cavity after extrapleural pnuemonectomy. An example of this is Intensity Modulated Radiation Therapy (IMRT), which uses x-rays of varying intensities in conjunction with computer generated images to deliver targeted radiation directly to cancer cells while reducing the amount of radiation to surrounding healthy tissue. More on Intensity Modulated Radiation Therapy (IMRT).

Used palliatively, radiation can help control metastases (spread) of the tumor along tracks left by invasive procedures such as thoracoscopy, needle biopsy and chest tube drainage, or to control disease symptoms, such as pain or shortness of breath.

An exciting new development in radiation oncology is tomotherapy. A brief description of steps in the helical tomotherapy process.

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A Word About Nutrition

all the above information is obtained from the following link.

http://www.mesotheliomaweb.org/treat.htm

The Emergence of President Obama's Muslim Roots

2009-06-03T06:58:00.000-07:00

ABC News' Jake Tapper and Sunlen Miller report: The other day we heard a comment from a White House aide that never would have been uttered during the primaries or general election campaign.

During a conference call in preparation for President Obama's trip to Cairo, Egypt, where he will address the Muslim world, deputy National Security Adviser for Strategic Communications Denis McDonough said "the President himself experienced Islam on three continents before he was able to -- or before he's been able to visit, really, the heart of the Islamic world -- you know, growing up in Indonesia, having a Muslim father -- obviously Muslim Americans (are) a key part of Illinois and Chicago."

Given widespread unease and prejudice against Muslims among Americans, especially in the wake of 9/11, the Obama campaign was perhaps understandably very sensitive during the primaries and general election to downplay the candidate's Muslim roots.

The candidate was even offended when referred to by his initials "BHO," because he considered the use of his middle name, "Hussein," an attempt to frighten voters.

With insane rumors suggesting he was some sort of Muslim Manchurian candidate, then-Sen. Barack Obama, D-Ill., and his campaign did everything they could to emphasize his Christianity and de-emphasize the fact that his father, Barack Obama Sr., was born Muslim.

The candidate's comment at a Boca Raton, Florida, town hall meeting on May 22, 2008, was typical: "My father was basically agnostic, as far as I can tell, and I didn't know him," he said.

In September 2008, candidate Obama told a Pennsylvania crowd, "I know that I'm not your typical presidential candidate and I just want to be honest with you. I know that the temptation is to say, 'You know what? The guy hasn't been there that long in Washington. You know, he's got a funny name. You know, we're not sure about him.' And that's what the Republicans when they say this isn't about issues, it's about personalities, what they're really saying is, 'We're going to try to scare people about Barack. So we're going to say that, you know, maybe he's got Muslim connections.'...Just making stuff up."

Back then, the campaign's "Fight the Smears" website addressed the candidate's faith without mentioning his father's religion:

"Barack Obama is a committed Christian. He was sworn into the Senate on his family Bible. He has regularly attended church with his wife and daughters for years. But shameful, shadowy attackers have been lying about Barack’s religion, claiming he is a Muslim instead of a committed Christian. When people fabricate stories about someone’s faith to denigrate them politically, that’s an attack on people of all faiths. Make sure everyone you know is aware of this deception."

The website also provided quotes from the Boston Globe and Newsweek mentioning his father's roots.

Since the election, however, with the threat of the rumors at least somewhat abated, the White House has been increasingly forthcoming about the president's roots. Especially when reaching out to theMuslim world.

In his April 6 address to the Turkish Parliament, President Obama referenced how many "Americans have Muslims in their families or have lived in a Muslim majority country. I know, because I am one of them."

- Jake Tapper and Sunlen Miller

all the above information is obtained from the following link.

http://blogs.abcnews.com/politicalpunch/2009/06/abc-news-jake-tapper-and-sunlen-miller-report-the-other-day-we-heard-a-comment-from-a-white-house-aide-that-neverwould-have.html

Air France: Missing plane probably crashed into Atlantic

2009-06-02T00:04:00.000-07:00

PARIS, France (CNN) -- The jet carrying 228 people from Rio de Janeiro, Brazil, that disappeared overnight as it entered an area of strong turbulence probably crashed into the Atlantic Ocean, the CEO of Air France said Monday.

Brazilian and French ships and planes were looking for any sign of the missing plane, authorities said.

The first three hours of what was to have been an 11-hour flight appear to have been uneventful, CEO Pierre-Henri Gourgeon said.

But about 4:15 a.m. Paris time, Flight 447's automatic system began a four-minute exchange of messages to the company's maintenance computers, indicating that "several pieces of aircraft equipment were at fault or had broken down," he said.

"This succession of messages signals a totally unforeseeable, great difficulty," he said. "Something quite new within the plane."

During that time, there was no contact with the crew, Gourgeon said.

"It was probable that it was a little bit after those messages that the impact of the plane took place in the Atlantic," he added.

He said the Airbus A330 was probably closer to Brazil than to Africa when it crashed.

He noted that turbulence made flying "difficult" in the area but that it is "too early to say" exactly what happened.

The chances of finding any survivors were "very low," French President Nicolas Sarkozy admitted Monday.

"This is a catastrophe the likes of which Air France has never seen before," he said at Charles de Gaulle International Airport, where he met with relatives of the missing.

"I said the truth to them: The prospects of finding survivors are very low," he said.

The airline company identified the nationalities of the victims as two Americans, an Argentinean, an Austrian, a Belgian, 58 Brazilians, five British, a Canadian, nine Chinese, a Croatian, a Dane, a Dutch, an Estonian, a Filipino, 61 French, a Gambian, 26 Germans, four Hungarians, three Irish, one Icelandic, nine Italians, five Lebanese, two Moroccans, three Norwegians, two Polish, one Romanian, one Russian, three Slovakian, two Spanish, one Swedish, six Swiss and one Turk.

An official list of victims by name was not available late Monday.

The American victims were identified as Michael Harris, 60, and his wife, Anne, 54, by the couple's family and his employer, Devon Energy in Oklahoma -- the largest U.S.-based independent natural gas and oil producer. Michael Harris was a company geologist in Rio de Janeiro, according to a company spokesman.

Anne Harris' sister, Mary Miley, told CNN the couple had been living in the city since July 2008 and that they were traveling to Paris for a training seminar for Michael and for a vacation.

"Anne and Mike were indeed a beautiful couple inside and out and I miss them terribly already," Miley said in an e-mail.

Sarkozy said French authorities sent ships and planes to the area about 250 miles (400 kilometers) from Brazil. "Our Spanish friends are helping us; Brazilians are helping us a lot as well."

French Transport Minister Jean-Louis Borloo told CNN affiliate France 2 that France asked the U.S. military to assist in the search through U.S. detection satellites. Pentagon officials in Washington did not immediately confirm the request.

Brazilian President Luiz Inacio Lula da Silva told reporters in San Salvador, El Salvador, that he had spoken with Sarkozy but neither leader knew what to say. "All we could do was thank each other," Lula said. "He thanked me for the speed with which the Brazilian air force took charge."

He added, "In times like these, there is little to do but to deeply lament, to wish the families a lot of strength, because there are no words in times like these."

Sarkozy said authorities were seeking the help of satellites that might be able to pick up signs of what happened to the 4-year-old Airbus 330.

No possibility was being excluded: Turbulence in the area was strong, but other planes were able to pass through it without incident, he said.

The plane reported a problem with the electrical system, "but the specialists refuse for the moment to express themselves about any possibility," Sarkozy said.

The jet also sent a warning that it lost pressure, the Brazilian air force said. Watch aviation expert describe possible scenarios »

It lost contact with air traffic control between Galeao International Airport in Rio de Janeiro and Charles de Gaulle International Airport in Paris, the airline said Monday.

The Airbus A330 sent out an automatic signal warning of the electrical problems just after 2 a.m. GMT Monday as it flew "far from the coast," said an Air France spokeswoman who declined to be identified. It had just entered a stormy area with strong turbulence, she said.

The jet was flying at an altitude of 35,000 feet and a speed of 521 mph, the air force said.

Among the passengers were 126 men, 82 women, seven children and a baby, in addition to the 12 crew members, Air France officials in Brazil said.

Much of the route is out of radar contact, Brazilian air force Col. Henry Munhoz told TV Globo.

The flight, AF 447, took off from Galeao International Airport at 11:30 p.m. Sunday GMT. It was scheduled to land in Paris at 9:10 a.m. GMT. Learn more about recent notable airplane crashes »

Its last known contact occurred at 2:33 a.m. GMT, the Brazilian air force spokesman said.

It was expected to check in with air traffic controllers at 3:20 a.m. GMT but did not do so, the Brazilian air force said in a statement.

Brazilian authorities asked the air force to launch a search mission just over three hours later, at 6:30 a.m. GMT, the statement said.

The plane reported no problems before takeoff, Joao Assuncao, Air France's manager in Brazil, told the country's Record TV.

The airline set up a crisis center at the Paris airport. It listed numbers for families to call: 0 800 800 812 for people in France and 00 33 1 57 02 10 55 for families outside France.

At a crisis center at the airport in Rio, relatives of the missing complained of a dearth of information from Air France, the Brazilian state news agency reported.

One man, who identified himself as Bernardo, said his brother, Romeo Amorim Souza, and his wife were on the missing flight.

"I came to the airport because I wasn't finding information, and my parents are very nervous," he told Agencia Brasil.

The missing A330 last underwent a maintenance check on April 16, the airline said.

CNN air travel expert Richard Quest said the twin-engine plane, a stalwart of transatlantic routes, had an impeccable safety record, with only one fatal incident involving a training flight in 1994.

"It has very good range and is extremely popular with airlines because of its versatility," he said.

Its crew was composed of three pilots and nine cabin crew members, including a captain who has logged 11,000 hours in flight. About 1,700 of those hours were on the A330 and A340. Of the two co-pilots, one has 3,000 hours of flying experience and the other 6,600 hours. The aircraft has flown 18,870 hours.

The model is "capable of communicating in several different ways over quite long distances even if they are out of radar coverage," said Kieran Daly of the online aviation news service Air Transport Intelligence.

The French Accident Investigation Bureau for civil aviation is investigating, the company said in a statement.

all the above information is obtained from the following link.

http://www.cnn.com/2009/WORLD/americas/06/01/air.france.brazil/index.html?eref=rss_topstories

2009-05-30T06:37:00.000-07:00

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Filed under: Aftermarket, Wagons/Estates, BMW, Rendered Speculation
Rendered Speculation: BMW M3 Touring wagon by Jon Sibal

Some of us live in the real world, while other spend time in Fantasyville. Jon Sibal falls into the latter, and we're happy for it. The talented illustrator had given us glimpses of upcoming supercars – including the Ferrari Scuderia Spider, Mercedes SLR Speedster (later revealed as the Stirling Moss edition) and Aston Martin One-77 – before the manufacturers have released official pictures. So what would Sibal drive himself? Well, needless to say, it doesn't exist (yet), but while you might think it'd be some fantastic derivative of an upcoming supercar, what Jon has picked out for himself is a BMW M3 Touring wagon.

The current-generation M3 is currently made in three bodystyles: the E90 sedan, E92 coupe and E93 convertible. If you were high astute enough to follow the psychedelic pinball counting cartoon on Sesame Street as a child, you'll have noticed that the E91 is missing from the equation. That's the designation for the current 3 Series station wagon. BMW's anticipated to roll out an M3 wagon sometime in the next few months, but Sibal's not waiting around, and has given us these renderings to hold us over. While he was at it, he dropped the ride height down to the floor with a KW coil-over suspension, fitted a titanium exhaust, AC Schnitzer spoilers front and back, BBS mags coated in Yokohama rubber and Brembo eight-pot brakes, then added a supercharger to the M3's V8 and painted it satin white for good measure. Not too shabby, and not too far-fetched, either. Who knows, if Sibal earns what he deserves, maybe this fantasy can become reality when BMW unleashes the latest M3 Touring on the world.

the above information is obtained from the following link

http://www.autoblog.com/2009/01/19/rendered-speculation-bmw-m3-touring-wagon-by-jon-sibal/

2009-05-26T20:08:00.000-07:00

we are adding constantly updated quality news stories opinion widgets and games widgets on the blog and representing it on the internet before anyone represent. click the older post button below to check these widgets and news stories and the coolest colection of concept cars you will never find coolest of images then this anywhere on the web.

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2009-05-25T20:30:00.000-07:00

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News widgets and RSS feeds on Feedzilla.com

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2009-05-24T20:51:00.000-07:00

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2009-05-24T20:14:00.000-07:00

Concept cars

Concept Cars: Automobiles for the Future No one knows where automobiles are going but concept cars provide us with a small window to look into their future. Different automakers use concept cars in various ways and they all devote a lot of time and money toward developing their cars of the future. The first thing an automaker does is decide what kind of market (what age group, what style of driving) it should target to gain the most customers. For instance, Ford builds mainly vehicles which target families with kids. Every year Ford comes out with new concepts appealing to families. Examples might include four doors, room for a dog, and the ability to go anywhere. Ferrari, on the other hand, builds cars for the rich auto enthusiast who likes to drive fast and race. Ferrari may come out with one new concept every year targeting this extreme group of car enthusiasts. All automakers create concept cars but they may explore different ideas and markets. In the beginning car design was simple. All cars had four wheels, a couple seats, a motor, and a steering wheel. Henry Ford offered his model T "in any color you want, as long as it's black." Today creating cars has become more complicated. Not only must a car look good

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